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Inhibitors of NADH:Q reductase (Complex I). Print E-mail
Article Index
Inhibitors of NADH:Q reductase (Complex I).
Page 2
 
Inhibitors of the mitochondrial Complex I.
See Ref. 1 for more detail.

Family of compounds and main useRepresentative inhibitorCASI50KiRelative
potencya
aThe relative potency is measured as the ratio of Ki values where they are available. See Ref. 1 for details.
bThese inhibitors are not specific to Complex I.
cRhein is not specific to Complex I.
daction different from rotenone
Pesticides Acaricides and Insecticides
Antihelmintic Benzimidazole251-17-23 nM
1.4
Pyrethroid insecticidesCyhalothrin468085-85-80.6 然
4x10-2
Insecticide (rotenoid from Leguminosae) Deguelin5522-17-84.2 nmol/mg
0.02
"MITE" group acaricideFenazaquin6120928-09-820 nM
0.5
"MITE" group acaricideFenpyroximate1,7134098-61-64.6 nM, 18 nM
1.1
"MITE" group acaricidePyridaben196489-71-32.4 nM
2
Insecticide, pesticide (Derris) Rotenone2,3,8 83-79-40.07 nmol/mg 4 nM1
"MITE" group acaricideTebufenpyrad1119168-77-36 nM
ca. 1
Drugs and toxins
Neurotoxin (brain metabolite)1,2,3,4-Tetrahydroisoquinoline9,1091 -21 -42 然
<10-5
OXPHOS uncoupler2,4-dinitrophenol1151-28-5150 然
1x10-4
Neurotoxin (deriv. of harmine, Zygophyllaceae)2-methylharmine1249296-40-2180然
6x10-5
Sedative (barbiturate)Amytal (Amobarbital)13,1457-43-2200 然
5x10-5
Antibiotic (Streptomyces)Aureothin2 2825-00-50.3 nmol/mg
0.23
Irritant, analgesic (Capsicum)Capsaicin15,16404-86-420-30 然
<0.001
OXPHOS uncouplerCCCP1555-60-285 然
2x10-4
AntihistaminicCinnarizine17298-57-7510 然
1x10-3
Mouth wash antisepticDequalinium chloride18522-51-011 然
3x10-3
NeurolepticHaloperidol1952-86-83 然
2x10-2
Analgesic (opiate)Meperidine (Pethidine)157-42-1100 然
1x10-4
Neurotoxin, herbicide (synthetic)MPP+ (Cyperquat)2039794-99-5300 然
3x10-5
Annonaceous acetogenin (Annonacea)Otivarin3 ?0.2 nmol/mg 0.9 nM>1
Vasodilator (opium)Papaverine21 61-25-65 然
0.006
Antibiotic (Myxobacteria, Polyangium)Phenoxan2 134332-63-10.04 nmol/mg
2
Antifungal (Pterula)Pterulone22 ?36 然
>0.003
AntianginalRanolazine23142387-99-323 然
2x10-3
NADH antagonist (Rhubarb)Rheinc 24 478-43-330 然2000 nM>0.002
Annonaceous acetogenin (Annonacea)Rolliniastatin-13 [102989-24-2]?0.03 nmol/mg 0.3 nM13
Annonaceous acetogenin (Annonacea)Rolliniastatin-2 or Bullatacind 3102989-24-20.06 nmol/mg0.6 nM6.7
Antibiotic (Myxobacteria, Polyangium)Thiangazole2 144370-38-70.04 nmol/mg
2
Piericidin (synthetic)Ubicidin-325 ?0.17 nmol/mg 1.5 nM2
Rodenticide (synthetic) Vacor (pyriminil)2653558-25-150 然
5x10-3
Q antagonistsb
Antibiotic (Myxobacteria, Stigmatella)Aurachin A2 108354-15-08.0 nmol/mg
0.01
Nootropic drug (synthetic)Idebenone27 58186-27-90.4 mM
0.01
Antibiotic (Strobiluris)Mucidin28 52110-55-1>100 nmol/mg
0.001
Antibiotic (Myxobacteria, Myxococcus)Myxothiazol28,29 76706-55-320 nmol/mg 100 nM0.04
Antibiotic (Streptomyces)Piericidin A2,3,30 2738-64-90.06 nmol/mg 1 nM>4
Antibiotic (Myxobacteria, Stigmatella)Stigmatellin28 91682-96-1100 nmol/mg
0.004
syntheticUbiquinone-227,31,32,33 7704-04-32 mM
0.003
Fluorescent dyes
CarbocyaninediOC5(3)3460031-82-51.5 然
5x10-2
CarbocyaninediOC6(3)3554501-79-080 nM
0.2
FluoresceinErythrosin 5 -iodoacetamide3586583-16-620 nM
0.8
PhenazineSafranine34477-73-617 然
2x10-3
Other chemicals
Carboxyl group -specific crosslinkerDCCD36538-75-0100 然
1x10-4
Flavin-specific reagentDiphenyliodonium3710182-84-00.23 然
<0.1
Metal chelatoro-Phenanthroline3866-71-7250 然
4x10-5

References
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